2024.04—至今????????中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院?? 研究員
2017.01—2024.04? ???中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院?? 副研究員
2012.07—2016.12? ???中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院?? 助理研究員
2006.09—2012.06?????中國(guó)科學(xué)技術(shù)大學(xué) ???結(jié)構(gòu)生物學(xué)專(zhuān)業(yè)?? 博士
2002.09—2006.06?????江西師范大學(xué)???生物科學(xué)專(zhuān)業(yè)???? 學(xué)士
(1) 分選轉(zhuǎn)運(yùn)相關(guān)蛋白調(diào)控內(nèi)涵體運(yùn)輸以及信號(hào)轉(zhuǎn)導(dǎo)的分子機(jī)制研究；
(2) 表觀遺傳調(diào)控因子或復(fù)合物的結(jié)構(gòu)與功能研究；
(3) 基于靶點(diǎn)結(jié)構(gòu)的藥物發(fā)現(xiàn)。
(1) 國(guó)家自然科學(xué)基金，面上項(xiàng)目，32171213，RGS-PX蛋白調(diào)節(jié)內(nèi)涵體上GPCR-G蛋白信號(hào)轉(zhuǎn)導(dǎo)的分子機(jī)制研究，2022.01-2025.12，75.40萬(wàn)，在研，主持
(2) 呼吸疾病全國(guó)重點(diǎn)實(shí)驗(yàn)室，自主項(xiàng)目，SKLRD-Z-202415，NudCMab調(diào)節(jié)膿腫分枝桿菌抵抗異煙肼和乙硫異煙胺的機(jī)制研究，2024.01-2026.12，20萬(wàn)元，在研，主持
(3) 廣州市科學(xué)技術(shù)局，基礎(chǔ)研究計(jì)劃一般項(xiàng)目，202201010030，SARS-CoV2引物酶nsp7-nsp8的催化機(jī)制研究，2022.04-2024.03，5萬(wàn)元，結(jié)題，主持
(4) 呼吸疾病國(guó)家重點(diǎn)實(shí)驗(yàn)室，自主項(xiàng)目，SKLRD-Z-202009，SNX13調(diào)節(jié)平滑肌舒張信號(hào)通路中β2AR-Gαs信號(hào)轉(zhuǎn)導(dǎo)的分子機(jī)制研究，2020.01-2022.12，20萬(wàn)元，結(jié)題，主持
(5) 國(guó)家衛(wèi)生健康委員會(huì)，國(guó)家科技重大專(zhuān)項(xiàng)(民口)，2018ZX09711002-003-007，針對(duì)RORγ前列腺癌藥物研發(fā)，2018.01-2020.12，115.33萬(wàn)，結(jié)題，任務(wù)負(fù)責(zé)人
(6) 國(guó)家科技部，國(guó)家重點(diǎn)研發(fā)計(jì)劃，2017YFA0504104，新型表觀遺傳調(diào)控蛋白因子和機(jī)器的結(jié)構(gòu)與功能研究，2017.07-2022.06，790萬(wàn)，結(jié)題，參與(骨干)
(7) ?國(guó)家自然科學(xué)基金，青年科學(xué)基金，31500638，淺藍(lán)霉素A生物合成通路中氨基轉(zhuǎn)移酶CrmG的結(jié)構(gòu)生物學(xué)研究，2016.01-2018.12，24萬(wàn)元，結(jié)題，主持
(8) 廣東省自然科學(xué)基金，博士啟動(dòng)，內(nèi)體溶酶體形態(tài)調(diào)控通路中SNX11的膜結(jié)合機(jī)制研究，2015.01-2018.01，10萬(wàn)元，結(jié)題，主持
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1.??Liangyu Xing#, Jinxin Xu#, Meihan Gong#, Yunzhi Liu#, Xuanyuan Li, Lingyu Meng, Ruyue Du, Ying Zhou, Zhaoguang Ouyang, Xu Liu, Shaofei Tao, Yuxin Cao, Chunyi Liu, Feng Gao, Ruohui Han, Hui Shen, Yan Dong, Yong Xu, Tao Li, He Chen, Yingying Zhao, Baoyou Fan, Lei Sui, Shiqing Feng, Jinsong Liu, Dayong Liu & Xudong Wu. Targeted disruption of PRC1.1 complex enhances bone remodeling. Nature Communications, 2025, 16: 4294.
2.??Wenjing Bai#, Jinxin Xu#, Wenbin Gu#, Danyang Wang#, Ying Cui#, Weidong Rong, Xiaoan Du, Xiaoxia Li, Cuicui Xia, Qingqing Gan, Guantao He, Huahui Guo, Jinfeng Deng, Ray-Whay Chiu Yen, Srinivasan Yegnasubramanian, Scott B. Rothbart, Cheng Luo, Linping Wu, Jinsong Liu, Stephen B. Baylin, Xiangqian Kong. Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy. Nature Communications, 2025, 16:474.
3.??Yulong Zhang#, Zhijun Yu#, Mingwei Sun, Ruyue Du, Hanhan Gao, Qiankun Dai, Yan Dong, Cuicui Liu, Menghui Yin, Tingting Xu, Xiaofei Zhang, Jinsong Liu*, Jinxin Xu*. Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes. Redox Biology, 2024, 75: 10325.
4.??Rui Chen, Feng Shen, Yulong Zhang, Mingze Sun, Yan Dong, Yue Yin, Chen Su, Chao Peng, Jinsong Liu*, Jinxin Xu*. Calcium modulates the tethering of BCOR-PRC1.1 enzymatic core to KDM2B via liquid-liquid phase separation. Communications Biology, 2024, 7(1):1112.
5.??Lingyu Meng, Zhaojian Sun, Yulong Zhang, Yan Dong, Xiaoan Du, Yujian Wu, Yuan Yuan, Yirong Sun, Yong Xu, Huaiwei Ding*, Jinsong Liu*, Jinxin Xu*. Structural Studies on Mycobacterial NudC Reveal a Class of Zinc Independent NADH Pyrophosphatase. Journal of Molecular Biology, 2024, 436(23):168864.
6.??Rui Chen, Kai Su, Yulong Zhang, Yiguang Zhu, Jinsong Liu*, Jinxin Xu*. Co-crystal structure provides insights on transaminase CrmG recognition amino donor L-Arg. Biochemical and Biophysical Research Communications, 2023, 675:41-45.
7.??Yulong Zhang, Rui Chen, Yan Dong, Jiabin Zhu, Kai Su, Jinsong Liu*, Jinxin Xu*. Structural studies reveal unique non-canonical regulators of G protein signaling homology (RH) domains in sorting nexins. Journal of Molecular Biology, 2022, 434(21): 167823.
8.??Jinxin Xu#, Xin Jiang#, Yulong Zhang, Yan Dong, Changli Ma, Hanqiu Jiang, Taisen Zuo, Rui Chen, Yubin Ke, He Cheng, Howard Wang, Jinsong Liu. Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Communications Biology, 2022, 5: 925.
9.??Jinxin Xu#*, Xiaowen Tang#, Yiguang Zhu, Zhijun Yu, Kai Su, Yulong Zhang, Yan Dong, Weiming Zhu, Changsheng Zhang, Ruibo Wu, Jinsong Liu*. Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition. Communications Biology, 2020, 3(1): 455.
10.??Jinxin Xu#, Leilei Zhang#, Yinghua Ye, Yongli Shan, Chanjuan Wan, Junfeng Wang, Duanqing Pei, Xiaodong Shu*, Jinsong Liu*. SNX16 regulates the recycling of E-Cadherin through a unique mechanism of coordinated membrane and cargo binding. Structure, 2017, 25(8), 1251-1263.
11.??Kai Su#, Tingting Xu#, Zhijun Yu, Jiabin Zhu, Yulong Zhang, Minhao Wu, Ying Xiong, Jinsong Liu, Jinxin Xu. Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS letters, 2017, 591(13), 2011-20182.
12.??You Wu, Tingting Xu, Jinsong Liu, Ke Ding*, Jinxin Xu*. Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943. Biochemical and Biophysical Research Communications, 2017, 487(2):339-343.
13.??Yiguang Zhu#, Jinxin Xu#, Xiangui Mei#, Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu*, Jinsong Liu*, Changsheng Zhang*. Biochemical and structural insights into the aminotransferase CrmG in caerulomycin biosynthesis. ACS Chemical Biology, 2016, 11: 943–952.
14.??Shaohua Guo#, Jinxin Xu#, Ioannis V Pavlidis, Dongming Lan, Uwe T Bornscheuer, Jinsong Liu*, Yonghua Wang*. Structure of product‐bound SMG1 lipase: active site gating implications. FEBS Journal, 2015, 282(23): 4538-4547.
15.??Jinxin Xu, Tingting Xu, Bin Wu, Yinghua Ye, Xiaojuan You, Xiaodong Shu, Duanqing Pei, Jinsong Liu. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. Journal of Biological Chemistry, 2013, 288(23): 16598-16605.
