中國科學(xué)技術(shù)大學(xué)學(xué)士、康奈爾大學(xué)博士，中盛溯源生物科技有限公司聯(lián)合創(chuàng)始人、首席技術(shù)官（CTO）。主要研究內(nèi)容：利用重編程、定向分化、和基因修飾等技術(shù)。開發(fā)hiPSC來源細胞藥物開發(fā)，參與承接科技部十三五和十四五國家重點研發(fā)計劃《干細胞制劑及應(yīng)用的標(biāo)準(zhǔn)化研究》和《干細胞及相關(guān)產(chǎn)品質(zhì)量控制及評價技術(shù)》，建立中國人群“超級供體”hiPSC庫、參與起草國內(nèi)首個《人誘導(dǎo)多能干細胞》標(biāo)準(zhǔn)、完成臨床級hiPSC建庫質(zhì)量復(fù)核。2022年9月首個iPSC來源間充質(zhì)樣細胞治療產(chǎn)品“NCR100注射液”獲得國家藥品監(jiān)督管理局藥品審評中心的臨床試驗?zāi)驹S可。

發(fā)表論文和專利

1. Zhang H, Su B, Jiao L, Xu ZH, Zhang CJ, Nie J, Gao ML, Zhang YV#, Jin ZB#. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China. Ann Transl Med. 2021 Feb;9(3):245. (#Corresponding)

2. Yu J, Zhao T, Ma A, Zhang Y, Zhang K, Cheng L, Deng H, Kang J, Jin Z, Pan G, Hao J, Zhang Y, Fu B, Hu S, Na J, Liu Y, Cao J, Wang L, Zhu H. 《人誘導(dǎo)多能干細胞團體標(biāo)準(zhǔn)》，中國細胞生物學(xué)會，2021 Jan.

3. 一種中腦多巴胺能神經(jīng)前體細胞及其制備方法和應(yīng)用, 專利申請?zhí)?01910169525.0

4. 視網(wǎng)膜色素上皮細胞及其制備方法和應(yīng)用，專利申請?zhí)?01910320076.5.

5. 一種腎上皮細胞及其制備方法和應(yīng)用，專利申請?zhí)?01910834502.7.

6. 一種間充質(zhì)干細胞及其制備方法和應(yīng)用，專利號ZL201910884482.4.

7. 一種微環(huán)游離型載體高效重編程血液細胞生成iPSC的方法, 專利號ZL201810252408.6

8. 一種通過蠑螈Oct4將人類血液細胞重編程為iPSC的方法, 專利號ZL201810137319.7 9. Wang AB, Zhang YV, and Tumbar T. (2017) Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J. 2017 Jan 4;36(1):61-78.

10. Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang YV, and Tumbar T. (2016) Signaling couples hair follicle stem cell quiescence with reduced H3K4/K9/K27me3 levels for proper tissue homeostasis. Nature Communications 2016 Apr 15;7:11278

11. Zhang YV, Johns L., Yu J. (2014) Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures. US Patent CDIN.P0055US.P1.

12. Zhang YV, White B.S., Shalloway D.I., Tumbar T. (2010) Stem cell dynamics in mouse hair follicles: a story from cell division counting and single cell lineage tracing. Cell Cycle 2010 Apr 19;9(8).

13. Zhang YV, Cheong J., Ciapurin N., McDermitt D.J., Tumbar T. (2009) Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell, Volume 5, Issue 3, 267-278.

14. Waghmare S.K., Bansal R., Lee J.*, Zhang YV*, McDermitt D.J., Tumbar T. (2008) Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J. 27(9):1309-20. (* equal contribution)

15. Osorio, K.M., Lee, S.E., McDermitt, D.J., Waghmare, S.K., Zhang, YV, Woo, H.N. Tumbar, T. (2008) Acute Myeloid Leukemia Factor 1 Controls Developmental but not Injury Driven Activation of Hair Follicle Stem Cells. Development, 135, 1059-1068.

16. Yao X., Zhang Y., Chen W., Dou Z. (2005) Patent: A new developed absorbent polymer for protein condensation. The State Intellectual Property Office of the People's Republic of China Patent No.: ZL200310106547.1

17. Dou Z., Ding X., Zereshki A., Zhang Y., Zhang J., Wang F., Sun J., Huang H., Yao X. (2004) TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett, 572: 51–56.