2022.09-至今，中科院廣州生物醫(yī)藥與健康研究院，副研究員

2022.01-2022.08，廣州國(guó)家實(shí)驗(yàn)室，助理研究員

2020.09-2021.12，生物島實(shí)驗(yàn)室，助理研究員

2017.09-2020.08，南方醫(yī)科大學(xué)珠江醫(yī)院，博士后

基因編輯與疾病動(dòng)物模型的構(gòu)建及治療

單細(xì)胞多組學(xué)解析疾病發(fā)生及細(xì)胞命運(yùn)調(diào)控機(jī)制

1.國(guó)家自然科學(xué)青年基金項(xiàng)目：利用 TMP蛋白調(diào)控系統(tǒng)和CRISPR基因編輯技術(shù)制作快速可逆誘導(dǎo)型肝損傷豬模型、81800555、2019/01-2021/12、項(xiàng)目負(fù)責(zé)人

2.廣州市科技計(jì)劃項(xiàng)目：Zswim4蛋白在骨細(xì)胞感知機(jī)械刺激及骨再生中的功能和機(jī)制研究、202201011037、2022/04-2024/03、項(xiàng)目負(fù)責(zé)人

3.國(guó)家重點(diǎn)研發(fā)計(jì)劃：基于hiHep/HepGL細(xì)胞和ZhJ-III裝置的混合型人工肝系統(tǒng)的構(gòu)建與開發(fā)、2018YFC1106400、2018/09-2021/06、項(xiàng)目參與者

1. Li L, Meng H, Zhang J, Liu Y, Zou Q, Gao Y, Yang H, Lai L. A tunable, rapid and precision drug control of protein expression by combining transcriptional and post-translational regulation system. J Genet Genomics. 2020 Nov 20;47(11):705-712.

2. Li L, Meng H, Zou Q, Zhang J, Cai L, Yang B, Weng J, Lai L, Yang H, Gao Y. Establishment of gene-edited pigs expressing human blood-coagulation factor VII and albumin for bioartificial liver use. J Gastroenterol Hepatol. 2019 Oct;34(10):1851-1859.

3. Li L, Zhang Q, Yang H, Zou Q, Lai C, Zhao Ping, Luo Z, Yang J, Chen Q, Wang Y, Newsome P, Frampton J, Maxwell P. H., Siu T, Tam S, Tse H, Qin B, Bao X, Esteban M*, and Lai L*. Fumarylacetoacetate hydrolase knockout rabbit model for hereditary tyrosinemia type 1. JBC. 2017 Mar 17;292(11):4755-4763.

4. Li N, Gou SX, Wang JW, Zhang QJ, Huang XY, Xie JK, Li L, Jin Q, Ouyang Z, Chen FB, Ge WK, Shi H, Liang YH, Zhuang ZP, Zhao XZ, Lian M, Ye YH, Quan LQ, Wu H, Lai LX, Wang KP. CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I. Molecular Therapy. 2021 Mar 3;29(3):1001-1015.

5. Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai C, Yang H, Li L, Liu Q, Shi H, Xu G, Zhao H, Wei H, Pei Z, Li S, Lai L, Li XJ. A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease. Cell. 2018 May 3;173(4):989-1002.e13.

6. Yang J,?Wang Y,?Zhou T,?Wong LY,?Tian XY,?Hong X,?Lai WH,?Au KW,?Wei R,?Liu Y,?Cheng LH,?Liang G,?Huang Z,?Fan W,?Zhao P,?Wang X,?Iba？ez DP,?Luo Z,?Li Y,?Zhong X,?Chen S,?Wang D,?Li L,?Lai L,?Qin B,?Bao X,?Hutchins AP,?Siu CW,?Huang Y,?Esteban MA,?Tse HF. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Mar 14;8(3):605-618.????????????????????

7. Wei S, Zou Q, Lai S, Zhang Q, Li L, Yan Q, Zhou X, Zhong H, Lai L. Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Scientific Reports. 2016 Jan 19;6:19648.

8. Lai S, Wei S, Zhao B, Ouyang Z, Zhang Q, Fan N, Liu Z, Zhao Y, Yan Q, Zhou X, Li L, Xin J, Zeng Y, Lai L, Zou Q. Generation of Knock-In Pigs Carrying Oct4-tdTomato Reporter through CRISPR/Cas9-Mediated Genome Engineering. PLoS One. 2016 Jan 12;11(1):e0146562.

9.Zou Q, Wang X, Liu Y, Ouyang Z, Long H, Wei S, Xin J, Zhao B, Lai S, Shen J, Ni Q,Yang H, Zhong H,Li L, Hu M, Zhang Q, Zhou Z, He J, Yan Q, Fan N, Zhao Y, Liu Z, Guo L, Huang J, Zhang G, Ying J, Lai L, Gao X. Generation of gene-targeted dogs using CRISPR/Cas9 system.JMol Cell Biol. 2015 Dec;7(6):580-583.

10. Wang Y, Fan N, Song J, Zhong J, Guo X, Tian W, Zhang Q, Cui F, Li L, Newsome PN, Frampton J, Esteban MA, Lai L. Generation of knockout rabbits using transcription activator-like effector nucleases. Cell Regen (Lond). 2014 Feb 5;3(1):3.